The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM

The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM

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Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size that results in numerous Racquet Sports - Shoes - Mens developmental problems, including intellectual disability, motor and speech delays, and seizures.Hitherto, over 30 MCPH causing genes (MCPHs) have been identified.Among these MCPHs, MCPH5, which encodes abnormal spindle-like microcephaly-associated protein (ASPM), is the most frequently mutated gene.

ASPM regulates mitotic events, cell proliferation, replication stress response, DNA repair, and tumorigenesis.Moreover, using a data mining approach, we have confirmed that high levels of expression of ASPM correlate with poor prognosis in Shooting Trousers several types of tumors.Here, we summarize the neurological and non-neurological functions of ASPM and provide insight into its implications for the diagnosis and treatment of MCPH and cancer.